Fig. 7: Intercellular communication network between TAM_GPNMB and epithelial cell subclusters as determined by Nichenet. | Cell Death & Disease

Fig. 7: Intercellular communication network between TAM_GPNMB and epithelial cell subclusters as determined by Nichenet.

From: Multiomics integration-based immunological characterizations of adamantinomatous craniopharyngioma in relation to keratinization

Fig. 7

A Heatmaps showing ligand‒receptor communication streams from E_C3/E_C4 clusters to TAM_GPNMB. Top, orange heatmap indicates the Pearson correlation of prioritized ligands from high to low, and red heatmap indicates the expression level of ligands in E_C3/E_C4 clusters. Middle, heatmap of ligand‒receptor pairs, coloured by interaction potential. Bottom, heatmap showing the ligand and predicted target genes, coloured by regulatory potential. B Spatial sections, named ST1 to ST4 samples, showing spatial spots with the top 25% signature score of predicted target genes in TAM_GPNMB which were colour-coded in red. Signature scores were calculated by the AddModuleScore function in Seurat. The black dotted lined areas represent keratins. C Heatmaps showing ligand‒receptor communication streams from TAM_GPNMB to E_C3/E_C4 clusters. (D) Spatial sections showing spatial spots with the top 25% signature score of predicted target genes in E_C3/E_C4 clusters which were colour-coded in red. The black dotted lined areas represent keratins.

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