Fig. 6: Transplantation of hmOEG-iNs into hippocampus of NOD-SCID mice. | Cell Death & Disease

Fig. 6: Transplantation of hmOEG-iNs into hippocampus of NOD-SCID mice.

From: Generation of functional neurons from adult human mucosal olfactory ensheathing glia by direct lineage conversion

Fig. 6

A, E Survival of hmOEG-iNs at 60 and 90 days post-transplant. GFP+ cells (green) co-express NEUROD1 (red; inset in A, arrowheads) or Stem 121 human antigen (red; inset in E, arrowheads), verifying the ectopic origin of these cells. (B–D, F–H) hmOEG-iNs survive within the brain parenchyma and stain positive for Tuj1 (red), MAP2 (red) and NeuN (red) neuronal markers (white arrowheads), suggesting conversion into neurons after transplantation. Nuclei were stained with DAPI (blue). Scale bar: 75 µm (A, E) and 25 µm (insets in A, E, B–D, F–H).

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