Fig. 1: Macrophages can be found in two phenotypes including M1 and M2. | Cell Death & Disease

Fig. 1: Macrophages can be found in two phenotypes including M1 and M2.

From: Biological impact and therapeutic implication of tumor-associated macrophages in hepatocellular carcinoma

Fig. 1

The M2 polarized macrophages are characterized with the expression of a number of receptors including CD163, CD206, CD209, FIZZ1 and Ym1/2 that can secrete different cytokines including CCL22. The M1 polarized macrophages are characterized with the expression of a number of receptors including iNOS, MHC-II, TLR-4, TLR-2, CD86 and CD80 that can secrete TNF-α, IL-1α and others. In cancer, the M2 polarized macrophages increase tumorigenesis, while the M1 polarized macrophages reduce cancer progression (created by Biorender.com).

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