Fig. 5: UBTD1 promotes colorectal cancer cell proliferation and migration via regulating glycolysis in vitro and in vivo. | Cell Death & Disease

Fig. 5: UBTD1 promotes colorectal cancer cell proliferation and migration via regulating glycolysis in vitro and in vivo.

From: The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis

Fig. 5

A, B Increased proliferation and migration ability in UBTD1 overexpression CRC cells can be reversed by HK2 knockdown in HCT116 and P53R cells via colony formation assay and transwell chamber assay. C, D Increased proliferation and migration ability in UBTD1 overexpression CRC cells can be reversed by treatment of 2-DG, a specific glycolysis inhibitor, in HCT116 and P53R cells via colony formation assay and transwell chamber assay. E Promotion of xenograft tumor growth caused by UBTD1 overexpression can be reversed by 2-DG treatment in nude mice. F Promotion of lung metastasis caused by UBTD1 overexpression can be reversed by 2-DG treatment in nude mice. *P < 0.05 indicates a significant difference between the indicated groups.

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