Fig. 7: A working model.
From: PRMT1 promotes Warburg effect by regulating the PKM2/PKM1 ratio in non-small cell lung cancer
Upon glucose intake, USP7 binds to PRMT1 protein to facilitate maintenance of its stability. PRMT1 increases the PKM2/PKM1 ratio through promoting gene transcription of PTBP1, which augments aerobic glycolysis and cell proliferation in NSCLC. Conversely, under glucose insufficiency, p53 is activated to inhibit USP7 expression, further promoting PRMT1 protein degradation and inhibiting aerobic glycolysis and proliferation in p53 wild-type NSCLC cells.
