Fig. 8: EZH2 deficiency represses the positive effect of NOP2 on lung cancer progression in vivo. | Cell Death & Disease

Fig. 8: EZH2 deficiency represses the positive effect of NOP2 on lung cancer progression in vivo.

From: NOP2 facilitates EZH2-mediated epithelial–mesenchymal transition by enhancing EZH2 mRNA stability via m5C methylation in lung cancer progression

Fig. 8

A–C Tumor growth and weight were monitored in mice. D, E IHC staining of tumor sections and western blot results of tumor proteins. Scale bar = 50 μm. F Images of lungs in an in vivo mouse metastatic tumor model and H&E staining images of lung sections. Scale bar = 100 μm. G Lung metastases in all mice and the number of nodules were counted. H Schematic summarizing the NOP2/EZH2/EMT axis and its role in modulating lung cancer progression. Statistical methods: one-way ANOVA (B, C, G). Data are presented as the mean ± SEM of at least 3 independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.

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