Fig. 1: ATM inhibition activates cGAS/STING pathway.
From: ATM inhibition enhance immunotherapy by activating STING signaling and augmenting MHC Class I
A Gene Set Enrichment Analysis plot for CYTOSOLIC DNA SENSING PATHWAY. B, C Immunoblots showing STING, p-STING, TBK1, p-TBK1 and β-actin expression level in vector control and ATM-KO CT26 cells and HCT116 cells. D qRT-PCR was used to measure the mRNA level of CCL5, CXCL10 in vector control and ATM-KO CT26 cells and HCT116 cells. E, F Immunoblots showing STING, p-STING, TBK1, p-TBK1 and β-actin expression level in CT26 cells and HCT116 cells treated with increasing dose of KU60019 for 24 h. G qRT-PCR was used to measure the mRNA level of CCL5, CXCL10 in CT26 cells and HCT116 cells treated with increasing dose of KU60019 for 24 h. * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001.
