Fig. 7: Radiation and anti-PD-L1 enhances lymphocyte function in ATM-deficient tumor model.
From: ATM inhibition enhance immunotherapy by activating STING signaling and augmenting MHC Class I
A–D Representative flow cytometry profiles of KI67 in CD3+ T cells (A), KI67 in CD3+ CD8+ T cells (B) from TIL of vector control CT26 tumors and their quantitative analysis (C and D). n = 4. E Quantitative analysis of the MFI of CD86 in CD45+ CD11c+ MHC-II+ cells from tumor-draining lymph node of vector control CT26 tumors. n = 4. F–K Representative flow cytometry profiles of KI67 in CD3+ T cells (F), KI67 in CD3+ CD8+ T cells (J), and perforin in CD3+ CD8+ T cells (H) from TIL of ATM-KO CT26 tumors and their quantitative analysis (I, J and K). n = 4. L Quantitative analysis of the MFI of CD86 in CD45 + CD11c+ MHC-II+ cells from tumor-draining lymph node of ATM-KO CT26 tumors. n = 4. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
