Fig. 8: The effect of AQP3-mediated macrophages on the urethane mouse model. | Cell Death & Disease

Fig. 8: The effect of AQP3-mediated macrophages on the urethane mouse model.

From: PPAR-γ/NF-kB/AQP3 axis in M2 macrophage orchestrates lung adenocarcinoma progression by upregulating IL-6

Fig. 8

A The method, concentration, and duration of urathane and clodronate liposomes intervention in C57BL/6 J mice. B Representative images of surface lung nodules in C57BL/6 J mice following 25 weeks of intervention. C Bar graph showing the number of surface lung nodules in different groups. D, E Flow cytometry analysis of the proportion of F4/80+CD206+ cells in different groups. F The method, concentration, and duration of urethane, GW1929, and IL-6 intervention in C57BL/6 J mice. G Representative images of surface lung nodules in C57BL/6 J mice after intervention with urethane, GW1929, and IL-6. H Bar graph showing the analysis of surface lung nodules in C57BL/6 J mice after intervention with urethane, GW1929, and IL-6. I HE staining and Ki-67 staining of lung nodule lesions in C57BL/6 J mice with different interventions. J, K Flow cytometry analysis of the proportion of F4/80+CD206+ cells in C57BL/6 J mice with urethane, GW1929, and IL-6 intervention. L The schematic diagram illustrates the proposed mechanism of AQP3 in the tumor microenvironment of LUAD. biw = twice a week; i.p. = intraperitoneal injections; Lipo = clodronate liposomes; qw = once a week; GW1929 = PPAR-γ activator. *P < 0.05, ***P < 0.001, ****P < 0.0001.

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