Fig. 7: Changes in steady-state level retinal metabolites in mouse retina lacking Shp2. | Cell Death & Disease

Fig. 7: Changes in steady-state level retinal metabolites in mouse retina lacking Shp2.

From: Age-related retinal degeneration resulting from the deletion of Shp2 tyrosine phosphatase in photoreceptor neurons

Fig. 7

Steady-state levels of retinal metabolites were measured by LC/MS from four-independent Shp2flox/flox (WT) and rodShp2−/− (KO) mouse retinas. A heatmap of changed metabolites in rodShp2−/− mouse retina (A). Volcano plot showing differential metabolites in rodShp2−/−compared to Shp2flox/flox mouse retina, horizontal line indicates changes with (p < 0.05) (B). Quantification of TUNEL staining in rodShp2−/−mouse retinas. Prefer-fixed retinal sections of Shp2flox/flox and rodShp2−/− mice were examined for cell death with in-situ localization of apoptosis using TUNEL and counted the number of TUNEL-positive cells over the entire retina (C). Data are mean ± SEM, (n = 4).

Back to article page