Fig. 2: Overview of metabolic characteristics and therapy targets of pancreatic cancer.
From: Emerging mechanisms and promising approaches in pancreatic cancer metabolism
In addition to cellular metabolism such as nucleotide metabolism, carbohydrate metabolism, amino acid metabolism, lipid metabolism and oxidative homeostasis, complex tumor microenvironment metabolism and body metabolism (outer gray circles) together construct the metabolic characteristics of pancreatic cancer. With the development of novel experimental methods, precise tracking detection, integrated multi-omics analysis and personalized metabolic therapy (arrows), therapeutic or sensitization targets (blue regular octagons in the middle layer) have gradually been revealed, which is expected to break through the barriers to pancreatic cancer treatment (innermost), bringing new hope for the diagnosis and treatment of pancreatic cancer.
