Fig. 7: CHIP-mediated BCAT1 degradation induces metabolic reprogramming. | Cell Death & Disease

Fig. 7: CHIP-mediated BCAT1 degradation induces metabolic reprogramming.

From: CHIP-mediated ubiquitin degradation of BCAT1 regulates glioma cell proliferation and temozolomide sensitivity

Fig. 7

Extracts from wild-type U87 cells, U87-CHIP and U87-CHIP/BCAT1K360R cells were analyzed using an LC-ESI-MS/MS system. A Heatmap showing a visualization of clustering analyses of metabolites identified from cell lines. B–J Relative levels of leucine, isoleucine, valine, citrate, fumarate, malate, succinate, lactate and ATP in different cell lines. K KEGG pathway analysis of the metabolomic data. Data were presented as mean ± SD, n = 5. * p < 0.05, ** p < 0.01, ***p < 0.001.

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