Fig. 1: OTUD3 regulates the survival and cell cycle of DLBCL cells. | Cell Death & Disease

Fig. 1: OTUD3 regulates the survival and cell cycle of DLBCL cells.

From: Rupatadine-inhibited OTUD3 promotes DLBCL progression and immune evasion through deubiquitinating MYL12A and PD-L1

Fig. 1

A Gene Set Enrichment Analysis (GSEA) on the differentiation of OTUD3 expression levels in TCGA-DLBCL samples (top 33% vs. bottom 66%), top 5 ranking enriched termed were shown. B Expression level of OTUD3 in constructed stable Farage cells(Vector, OE-OTUD3, NC, sh-OTUD3). C CCK-8 assay on stable Farage cells. D LDH assay on stable Farage cells. E EdU assay on stable Farage cells. F Apoptosis rate of cells in all groups. G Proportion of cells undergoing activation of CASP3 in all groups. H Statistical analysis of apoptosis and active CASP3 experiments. I Intracellular calcium ion concentrations in all groups. J Mitochondrial activity in all groups. K Expression levels of apoptotic regulatory proteins. L, M Cell cycle distribution in all groups. N Expression levels of cell cycle regulatory proteins. Error bars represent the mean (n = 3) ± S.D. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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