Fig. 2: Rupatadine inhibits the survival and cell cycle of DLBCL cells. | Cell Death & Disease

Fig. 2: Rupatadine inhibits the survival and cell cycle of DLBCL cells.

From: Rupatadine-inhibited OTUD3 promotes DLBCL progression and immune evasion through deubiquitinating MYL12A and PD-L1

Fig. 2

A Virtual docking analysis between the OTU domain of OTUD3 and Rupatadine(Rupa). B Expression level of OTUD3 under Rupa treatment. C EdU assay on Rupa treated stable Farage cells. D LDH assay on Rupa treated stable Farage cells. E CCK-8 assay on Rupa treated stable Farage cells. F Apoptosis rate of cells in all Rupa-treated groups. G Proportion of cells undergoing activation of CASP3 in all Rupa-treated groups. H Statistical analysis of apoptosis and active CASP3 experiments. I Intracellular calcium ion concentrations in all Rupa-treated groups. J Mitochondrial activity in all Rupa-treated groups. K Expression levels of apoptotic regulatory proteins under Rupa treatment. L, M Cell cycle distribution in all Rupa-treated groups. N Expression levels of cell cycle regulatory proteins under Rupa treatment. Error bars represent the mean (n = 3) ± S.D. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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