Fig. 2: ALDH1A1 deficiency promoted tumor suppression by the immune system in vivo. | Cell Death & Disease

Fig. 2: ALDH1A1 deficiency promoted tumor suppression by the immune system in vivo.

From: ALDH1A1 promotes immune escape of tumor cells through ZBTB7B-glycolysis pathway

Fig. 2

Tumor growth curves of (A) confounding negative control (Ctrl) and two shAldh1a1 (#M1 and #M2) transfected CT26 xenografts in BALB/c mice and (B) Kaplan–Meier survival curves. C T cell killing assay in CT26 cells transfected with shAldh1a1 (#M1 and #M2) or control (Ctrl). D, E CD3+ and CD3+ CD8+, GZMB+ CD8+ TILs and quantitative statistics of BALB/c mouse tumor tissue in shAldh1a1 (#M1 and #M2) and control group (Ctrl) by flow cytometry. F, G CD3+ and CD8+ PD-1+, CD8+ Tim3+ TILs and quantitative statistics of BALB/c mouse tumor tissue in shAldh1a1 (#M1 and #M2) and control group (Ctrl) by flow cytometry. Results were presented as mean ± S.D., n = 3–5. ns not significant; *P < 0.05, **P < 0.01, ***P < 0.001.

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