Table 1 Univariate and multivariate analysis for PFS in EGFR–TKIs monotherapy cohort.

From: PD-L1 induces autophagy and primary resistance to EGFR–TKIs in EGFR-mutant lung adenocarcinoma via the MAPK signaling pathway

Characteristics

Univariate analysis HR (95% CI)

p-value

Multivariate analysis HR (95% CI)

p-value

Sex male/female

1.398 (0.817–2.392)

0.222

  

Age ≥ 60/ < 60 years old

1.008 (0.584–1.740)

0.976

  

Smoking history yes/no

1.394 (0.798–2.435)

0.244

  

TNM stage IV/III

1.514 (0.735–3.119)

0.260

  

ECOG ≥ 2/0-1

14.508 (3.445–61.096)

< 0.001

17.101 (3.814–76.678)

< 0.001

Brain metastasis yes/no

0.603 (0.256–1.423)

0.248

  

Liver metastasis yes/no

1.036 (0.464–2.310)

0.932

  

Bone metastasis yes/no

1.043 (0.598–1.819)

0.883

  

PD-L1 positive/negative

2.147 (1.178–3.915)

0.013

2.222 (1.216–4.060)

0.009

  1. HR Hazard ratio, TNM Tumor node metastasis, ECOG Eastern Cooperative Oncology Group.
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