Table 3 The top 20 interaction pairs between cell types.

From: A spatiotemporal comparative analysis on tumor immune microenvironment characteristics between neoadjuvant chemotherapy and preoperative immunotherapy for ESCC

Ligand cell

Receptor cell

Ligand gene

Receptor gene

Secreted

Epithelial cells

T cells

TNFSF9

TNFRSF9

Fibroblasts

Fibroblasts

DPP4

CCL11

Mast cells

Fibroblasts

ADCYAP1

DPP4

Epithelial cells

B Cells

TNFSF9

ADGRG5

T cells

Epithelial cells

XCL1

ADGRV1

ECs

Epithelial cells

PDGFB

ADGRV1

Mural cells

ECs

CCL8

ACKR1

ECs

Fibroblasts

PDGFB

PDGFR

B cells

T cells

TNFRSF13B

CD70

Epithelial cells|

Plasma cells

CDH1

aEb7

×

ECs

Fibroblasts

PDGFB

PDGFRA

Epithelial Cells

ECs

COL9A3

a10b1

Epithelial cells

ECs

EFNA3

EPHA4

×

Fibroblasts

ECs

COL16A1

a10b1

Epithelial cells

ECs

EFNA4

EPHA4

Fibroblasts

ECs

COL10A1

a10b1

Fibroblasts

ECs

VEGFD

KDR

Fibroblasts

ECs

COL4A4

a10b1

Epithelial cells

Mast cells

PLXNB1

SEMA4D

  1. Interaction pairs between cell types in ESCC was explored and the top 20 interaction pairs was displayed. Ligand cells, receptor cells, ligand genes and receptor genes are labeled separately. If the interaction is in the form of secretion, it is “√“, otherwise it is “ד.