Fig. 7: Proposed model of the action of galectin-8 in CRC. | Cell Death & Disease

Fig. 7: Proposed model of the action of galectin-8 in CRC.

From: B4GALT1-dependent galectin-8 binding with TGF-β receptor suppresses colorectal cancer progression and metastasis

Fig. 7

CRC cells showed increased levels of B4GALT1. In the absence of galectin-8 (left), TGF-β binds to TβRII, thereby promoting EMT. In the presence of galectin-8 (right), galectin-8 binds to TβRII through B4GALT1-mediated galactosylation of N-glycans, resulting in a decrease of TGF-β signaling-mediated EMT.

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