Fig. 9: Mechanisms of the PIM1 kinase signaling pathway regulates EMT-associated osimertinib-resistant NSCLC.

PIM1 suppresses the ubiquitin-proteasome degradation of SNAIL and SLUG by deactivating GSK3β through phosphorylation. The stability and accumulation of SNAIL and SLUG facilitate EMT and encourage osimertinib resistance.