Fig. 2: MSCs promote progression of bladder cancer cells in vitro and in vivo. | Cell Death & Disease

Fig. 2: MSCs promote progression of bladder cancer cells in vitro and in vivo.

From: Mesenchymal stem cells in tumor microenvironment: drivers of bladder cancer progression through mitochondrial dynamics and energy production

Fig. 2

The colony formation (a), EdU (b), wound healing (c), and transwell assays (d) showed a significant enhancement in bladder cancer cell proliferation, migration, and invasion abilities after co-culture with MSCs. Western blot analysis showed an increase in the expressions of N-cadherin and Vimentin, while a decrease in the expression of E-cadherin was observed after co-culture with MSCs (e). The animal treatment timeline(f). The tumor formation in the co-injection group was faster than the control (g). Tumors of the co-injection (n = 4) and MSCs group (n = 4) grew significantly more quickly than those in the control group (n = 4) at different time points (h). The net weight of tumors in the co-injection and MSC group was increased compared with that of the control (i). *P < 0.05, **P < 0.01, ***P < 0.001.

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