Fig. 11: Gαi3 expression is correlated with immune cell infiltration of pancreatic cancer.
From: Identification of Gαi3 as a promising molecular oncotarget of pancreatic cancer
Analysis based on TCGA-PAAD cohort shows the Gαi3’s association with various immune cell populations (A). The scatter plot shows the specific correlation between Gαi3 expression and the proportion of macrophages in pancreatic cancer tissues (B). Multiplex immunohistochemistry (mIHC) staining on tissue microarrays from pancreatic cancer patients, categorized by high (C) and low (D) Gαi3 expression levels, is presented alongside a color legend for the markers used. Different colors represent specific markers: Gαi3 in red, CD163 in turquoise, HLA-DR in white, CD68 in green, PANCK in pink, PDL1 in gold, and DAPI as the nuclear counter-stain. Quantitative analysis subsequent to the staining process allowed for the comparison of immune cell populations between the groups with high and low Gαi3 expression. The percentages of M1 macrophages (E), M2 macrophages (F), and PDL1 positive cells (G) were shown. The terms “low-exp” and “high-exp” are utilized to denote groups with low and high Gαi3 expression, respectively. *P < 0.05 versus “low-exp” group. “N. S.” stands for P > 0.05. Scale bar = 100 μm.
