Fig. 2: Summary of RNA-Seq data for DMSO and BR0063-treated SWI/SNF LOF tumor cells. | Cell Death & Disease

Fig. 2: Summary of RNA-Seq data for DMSO and BR0063-treated SWI/SNF LOF tumor cells.

From: Hypermethylation of CDKN2A CpG island drives resistance to PRC2 inhibitors in SWI/SNF loss-of-function tumors

Fig. 2

A The number of genes significantly down- or up-regulated (fold change >1.5 and FDR < 0.05) in BR0063-treated SWI/SNF LOF cell lines compared with the DMSO group for 6 days of treatment are shown. B A Venn diagram showing the 564 commonly up- or down-regulated genes identified upon incubation of the sensitive cell lines DMS 114 and MFE-296 with BR0063. C KEGG analysis of the 564 commonly up-and down-regulated genes in the DMS 114 and MFE-296 cells demonstrates that cellular senescence, cell cycle, and DNA replication pathways are commonly regulated via PRC2/EED inhibition. D Heatmap analysis for Log2 fold changes (BR0063-treated vs. DMSO-treated) of differentially expressed genes in the KEGG DNA replication pathway and of selected genes in the KEGG cell cycle pathway, with purple implying decreased expression while orange implies increased expression. E GSEA analysis of Log2 fold changes (BR0063-treated vs. DMSO-treated) of differentially expressed genes in the KEGG DNA replication pathway in DMS 114, MFE-296, HuTu-80, and TOV-112D cells. NES means normalized enrichment score.

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