Fig. 3: Deletion of Nme8 leads to testis damage after CP stimulation for 2 weeks. | Cell Death & Disease

Fig. 3: Deletion of Nme8 leads to testis damage after CP stimulation for 2 weeks.

From: Nme8 is essential for protection against chemotherapy drug cisplatin-induced male reproductive toxicity in mice

Fig. 3

A Schematic of the administration method and timeline. B Body image of mice after CP injection for 2 weeks. C Changes in body weight of mice before and after CP administration. n = 4 biologically independent mice. D–F The morphology and weights of the testis and epididymis in different groups. Scale bar = 5 mm. n = 4 biologically independent mice. G H&E staining was performed for the testis and epididymis of different groups of mice. The enlarged image inside the black and red dotted boxes is on the right; the red asterisk marked the seminiferous tubule in which no spermatocyte was observed; black double arrows indicated the thickness of the seminiferous tubule; red arrows indicated vacuoles. Scale bar = 50 μm. H Representative diagram of vacuoles in the seminiferous tubules of Nme8−/−+CP mice. Scale bar = 50 μm. I Statistical results of the thickness of the seminiferous tubules. n = 6 biologically independent mice. J Statistics on the number of spermatocytes and round spermatids in per tubule. n = 4 biologically independent mice. *P < 0 .05, **P < 0.01, ***P < 0.001, NS indicates non-significant.

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