Fig. 6: An imbalance in the redox system was observed in the testes of Nme8−/− mice stimulated with CP. | Cell Death & Disease

Fig. 6: An imbalance in the redox system was observed in the testes of Nme8−/− mice stimulated with CP.

From: Nme8 is essential for protection against chemotherapy drug cisplatin-induced male reproductive toxicity in mice

Fig. 6

A Protein structure diagram of NME8. ROS activity was examined in the (B) testis and (C) sperms. D The concentration of MDA in the testis was measured. E, F Western blot results for 4-hydroxynonenal (4-HNE) were obtained from the testes of WT, WT + CP, and Nme8−/−+CP mice. G, H The proteins ALOX15 and (I, J) GPX4 were tested in the testis by western blot. The activity of SOD, GST, and TPX were measured by Elisa assay in the testes of WT, WT + CP, and Nme8−/−+CP mice, respectively. *P < 0 .05, **P < 0.01, ***P < 0.001, NS indicates non-significant, n = 4 biologically independent mice in each group.

Back to article page