Fig. 6: IDO1 can support SIRT1 functionality in BMDCs through NAD+ synthesis.
From: Sirtuin 1 regulates the phenotype and functions of dendritic cells through Ido1 pathway in obesity
Kynurenine pathway schema representing the hypothesis of the IDO1-SIRT1 axis (A). MFI (mean fluorescent intensity) of MHC-II and CD40 of BMDCs (with or without 2 mM of Acetylated-NAD) extracted from WT or IDOKO mice on 12 weeks of SD or HFD treatment (B–E). ELISA of IL-12p40 in BMDCs supernatant (with or without 2 mM of Acetylated-NAD) extracted from WT or IDOKO mice on 12 weeks of SD or HFD treatment (F and G). The significance values (p) followed the order: *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001, which were determined by the One-way ANOVA test or t-test when necessary, using GraphPad Prism®. The graphs and illustrations represent a representative experiment of three distinct experiments, with 3–6 animals per group.
