Fig. 2: Exercise regulates hippocampal gene expression in HFD-fed mice. | Cell Death & Disease

Fig. 2: Exercise regulates hippocampal gene expression in HFD-fed mice.

From: Regular exercise ameliorates high-fat diet-induced depressive-like behaviors by activating hippocampal neuronal autophagy and enhancing synaptic plasticity

Fig. 2

A PCA plot (n = 3). B Venn diagram. C Volcano plots of differential gene expression levels between groups (Con_H: the Control group; HFD_H: the HFD group; HRT_H: the RUN group). Significantly differentially expressed genes are shown in different colors; the blue dots indicate downregulated genes, and the red dots indicate upregulated genes. D Heatmap of the top 10 DEGs (Control: the Control group; HFD: the HFD group; Exercise: the RUN group). E Results of PCR validation (n = 4). F Correlation analysis of Wnt5a expression with the results of behavioral tests (n = 3). All the results are presented as the means ± standard deviations (SDs) with statistical significance (*P < 0.05, **P < 0.01, ns: P > 0.05).

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