Fig. 4: Radiation-resistant and radiation-sensitive PCa cells have distinct transcriptomes. | Cell Death & Disease

Fig. 4: Radiation-resistant and radiation-sensitive PCa cells have distinct transcriptomes.

From: Loss of miR-200c-3p promotes resistance to radiation therapy via the DNA repair pathway in prostate cancer

Fig. 4

A Volcano plot of differentially expressed mRNAs in DU145 RR cells compared to DU145 cells. The red dots on the left represent significantly downregulated mRNAs in DU145 RR cells, and those on the right represent upregulated mRNAs compared to those in DU145 cells. In green, mRNAs with a log2FC > 0.5 or <-0.5 are shown. In red, mRNAs with an adjusted p value < 0.05. B Volcano plot of differentially expressed mRNAs in DU145 RR cells transfected with miR-200c-3p versus those transfected with a control miRNA. The red dots on the left represent significantly downregulated mRNAs in DU145 RR cells transfected with miR-200c-3p, and those on the right represent upregulated mRNAs compared to those in cells transfected with control miRNA. In green, mRNAs with a log2FC > 0.5 or <−0.5 are shown. In red, mRNAs with an adjusted p value < 0.05. C Top8 of KEGG pathway enrichment of the DU145 RR-deregulated mRNAs D Top8 of KEGG pathway enrichment of the miR-200c-3p transfected DU145 RR-deregulated mRNAs. E Upset plot showing intersections between mRNAs predicted to be miR-200c-3p targets through algorithms (predict), mRNAs upregulated in radioresistant cells (RR), and mRNAs downregulated in DU145 RR cells transfected with miR-200c-3p (miR). Right, list of the 19 mRNAs common to all three groups.

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