Fig. 1: LCN2 is aberrantly expressed in GC and correlates with the positive prognosis of patients. | Cell Death & Disease

Fig. 1: LCN2 is aberrantly expressed in GC and correlates with the positive prognosis of patients.

From: Tumor-secreted LCN2 impairs gastric cancer progression via autocrine inhibition of the 24p3R/JNK/c-Jun/SPARC axis

Fig. 1

A LCN2 mRNA expression was negatively correlated with GC grade in our cohort. B Detection of LCN2 protein levels in GC tissues and their paired adjacent normal tissues using western blot (n = 10). C, D LCN2 protein expression was negatively correlated with GC grade in our cohort. E, F mRNA and protein expression levels of LCN2 in GES-1 and various GC cells. G TCGA and KM-plot database showed that LCN2 overexpression correlated with better prognosis. H Kaplan–Meier survival analysis revealed that low expression of LCN2 is correlated with shorter overall survival times in our cohort (n = 94, p < 0.001; log-rank test). I Correlation analysis between LCN2 expression and CDH1, CDH2, VIM, and ZEB1 expression in GC from the TCGA database. Data are presented as mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.

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