Fig. 5: Transcriptomic sequencing with participant inclusion. | Cell Death & Disease

Fig. 5: Transcriptomic sequencing with participant inclusion.

From: Nicotine-induced CHRNA5 activation modulates CES1 expression, impacting head and neck squamous cell carcinoma recurrence and metastasis via MEK/ERK pathway

Fig. 5

A Volcano plot illustrating differential gene expression. Gray indicates genes with non-significant differential expression, while red and blue denote genes with significant differential expression. B Heatmap of differentially expressed genes. Red signifies relatively high expression of protein-coding genes, whereas blue represents relatively low expression of protein-coding genes. Enrichment analysis. C Differential gene enrichment analysis using Gene Ontology (GO) (NC-SH). D Enrichment analysis of differential genes using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways (NC-SH). The horizontal axis represents the Enrichment Score, while the vertical axis represents the categories. Bubble size reflects the number of differentially expressed protein-coding genes, and color changes from blue to red indicate the significance of enrichment p-values, with larger bubbles being more significant. E Enrichment analysis of differential genes using Reactome pathways (NC-SH). F Enrichment analysis of differential genes using WikiPathways (SH-NIC).

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