Fig. 3: Effects of ferrostatin-1 on podocyte injury induced by OTUB1 downregulation in lupus nephritis.
From: OTUB1 regulation of ferroptosis and the protective role of ferrostatin-1 in lupus nephritis

A, B Treatment with Ferrostatin-1 improved conditions in OTUB1-deficient podocytes, evidenced by the restoration of SLC7A11 expression, reduction in MDA levels, and increase in cysteine and glutathione levels, and elevated Fe2+ levels and BODIPY C11 expression. C Restoration of nephrin and podocin expression in podocytes treated with Ferrostatin-1. Data are represented as mean ± SD. *p < 0.05, **p < 0.01,***p < 0.001.