Fig. 5: Effect of Ferrostatin-1 on renal damage in MRL/lpr mice with lupus nephritis. | Cell Death & Disease

Fig. 5: Effect of Ferrostatin-1 on renal damage in MRL/lpr mice with lupus nephritis.

From: OTUB1 regulation of ferroptosis and the protective role of ferrostatin-1 in lupus nephritis

Fig. 5

A Pathway analysis showed downregulation of inflammation, fibrosis, apoptosis, and complement pathways after Ferrostatin-1 application. B The TUNEL assay showed that treatment with Ferrostatin-1 significantly reduced renal cell apoptosis in 20-week-old MRL/lpr mice. Scale bar: 100 μm. C–F Immunohistochemical and western blot analyses revealed that Ferrostatin-1 treatment significantly reduced α-SMA and fibronectin expression, while also decreasing p65 expression and C3 deposition. Scale bar: 20 μm.

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