Fig. 1: USP11 was upregulated in CRC tissues.

A Relative expression levels of USP11 mRNA in CRC tissues compared with adjacent normal tissues (n = 10) from CRC patients. B Representative images of the immunohistochemical staining for USP11 in clinical samples. Scale bar: 20 μm. Statistical analysis of the expression of USP11 in CRC tissues. C, D Relative mRNA and protein expression levels of USP11 in colorectal homogenates of mice. E Macroscopic view of typical colorectal images after mice were euthanized. F The number of colorectal tumors in mice was measured. Each dot represents the tumor number of one mouse. G The number of tumors of different sizes (diameter) in each mouse were shown.