Fig. 5: USP11 regulated mitochondrial apoptosis in a Nrf2 dependent manner. | Cell Death & Disease

Fig. 5: USP11 regulated mitochondrial apoptosis in a Nrf2 dependent manner.

From: The USP11/Nrf2 positive feedback loop promotes colorectal cancer progression by inhibiting mitochondrial apoptosis

Fig. 5

HCT116/DLD1 cells were transfected with siRNAs to knock down USP11 protein and then transfected with plasmid to overexpress Nrf2. Statistical analysis of the total ROS (A), mitoSOX (B), GSH (C) and ATP (F) levels. (n = 3). D Apoptosis rate was assayed. Overexpression of Nrf2 could reverse the cell apoptosis caused by USP11 knockdown. (n = 3). E Representative images by immunofluorescence showed mitochondrial membrane potential. (n = 3). Scale bar: 50 μm.

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