Fig. 3: CCL19+ fibroblasts accumulated in the intra-tumor immune infiltration. | Cell Death & Disease

Fig. 3: CCL19+ fibroblasts accumulated in the intra-tumor immune infiltration.

From: DKK1+ tumor cells inhibited the infiltration of CCL19+ fibroblasts and plasma cells contributing to worse immunotherapy response in hepatocellular carcinoma

Fig. 3

A The single-cell dataset was divided into six main clusters: epithelial cells, myeloid cells, fibroblasts, endothelial cells, T cells, and B cells. B Distribution of CCL19 in single-cell dataset. C The plot displayed the correlation between CCL19 and DCN in the spatial transcriptomics data. D The plot displayed the correlation between CCL19 and DCN in the bulk transcriptomics data. E The multiplex immunofluorescence (MIF) perfomed in 20 hepatocellular carcinoma (HCC) patients demonstrated the co-location between CCL19 and DCN. F Immunohistochemistry (IHC) was performed on these samples to assess CCL19 expressiono in immune activation and immune exclusion samples. G HCC patients with high CCL19 levels had longer overall survival (OS) time. H The top 10 upregulated genes in CCL19+ and CCL19- fibroblasts. I Bar chart displaying the up-regulated and down-regulated pathways in CCL19+ fibroblasts. J Expression patterns of the most varied transcription factors (TFs) in CCL19+ fibroblasts.

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