Fig. 7: Model for how p53 imposes a cell cycle arrest after two failed cytokinesis in AURKBi-treated cells. | Cell Death & Disease

Fig. 7: Model for how p53 imposes a cell cycle arrest after two failed cytokinesis in AURKBi-treated cells.

From: Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition

Fig. 7

A P53 is induced after the first failed cytokinesis but this is too late to block S phase progression or impose the DREAM repression of S/G2/M phase genes. However, these genes are cell cycle regulated at both mRNA and protein levels and will be downregulated after the second failed cytokinesis. B AURKBi imposed senescence by both increased p53 activity and hypophosphorylation of RB resulting repression of the overlapping RB and DREAM repressor gene expression. In the absence pf p53, hypophosphorylation of RB is sufficient to promote senescence albeit this is delayed.

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