Table 3 Application of copper nano-complexes in CNS diseases.
From: Copper homeostasis and cuproptosis in central nervous system diseases
Copper nano-complex | Type of disease/subject | Mechanism | Ref |
|---|---|---|---|
Au@MSN-Cu/PEG/DSF | Tumor cell | Biodegradation induced by photothermal induction of material carrying Cu and DSF-inducing tumor cell cuproptosis | [140] |
L-/D-Pen@Se NPs | Alzheimer’s disease | Inhibition of copper induced Aβ deposition | [133] |
MXenzyme | Alzheimer’s disease | Chelates copper and scavenges ROS to reduce Aβ deposition | [157] |
HSA-BFP@CDs | Alzheimer’s disease | Detects and inhibits Aβ aggregation, mitigates oxidative stress | [158] |
PEG-PAsp(DET) | Ischemic stroke | Targeted repair of vascular injury after ischemic stroke | [159] |
nano IVA | Huntington’s disease | Activates cellular autophagy and reduces neuronal damage | [149] |
CuO-NPs | C6 glioma cells | Induction of cytotoxic injury in C6 glioma cells by copper accumulation | [130] |
Au@Cu2-xSe NPs | Glioblastoma | Inhibition of protective autophagy and DNA repair in glioma cells enhances the efficacy of radiotherapy | [160] |
CuHARS | CRL2303 Glioma | Increased inflammatory stressors induce glioma cell necrosis | [161] |
AngMNPs@ (Dp44mT/Reg) NPs | glioblastoma multiforme | Targeted increase of copper concentration in tumor cells induce apoptosis | [162] |
64Cu-AuNCs | Pontine gliomas | Quantifying the efficiency of targeted drug delivery | [132] |
