Fig. 3: MALAT1 restores the ferroptosis sensitivity inhibited by HBX in the GCB-type DLBCL cells. | Cell Death & Disease

Fig. 3: MALAT1 restores the ferroptosis sensitivity inhibited by HBX in the GCB-type DLBCL cells.

From: LncRNA MALAT1 promotes Erastin-induced ferroptosis in the HBV-infected diffuse large B-cell lymphoma

Fig. 3

A The CCK-8 assays for cell viability of the Ctrl and HBX-overexpressing SUDHL-4 and DB cells after 24 h of treatment with the indicated doses of Erastin. B The CCK-8 detection for the IC50 value of Erastin in the Ctrl and HBX-overexpressing SUDHL-4 and DB cells. C qRT–PCR analysis for the expression of MALAT1 in the Ctrl, HBX-overexpressing, and HBX-overexpressing cells transfected with MALAT1. “*” represented the significance of HBX versus Ctrl. “#” represented the significance of HBX + MALAT1 versus HBX. DG. qRT-PCR analysis (D and E) and western blot analysis (F and G) for the expression of SLC7A11, ACSL4, and GPX4 in the Ctrl, HBX-overexpressing, and HBX-overexpressing cells transfected with MALAT1. “*” represented the significance of HBX versus Ctrl. “#” represented the significance of HBX + MALAT1 versus HBX. H-K. The CCK-8 (H), MDA (I), and lipid peroxidation (J and K) analysis for the effect of HBX and MALAT1 in SUDHL-4 and DB cells after Erastin treatment. “*” represented the significance of HBX versus Ctrl. “#” represented the significance of HBX + MALAT1 versus HBX. The results were determined in triplicate, and the error bars represented the mean ± SD. ns P > 0.05, */# P < 0.05, **/## P < 0.01, and ***/### P < 0.001.

Back to article page