Fig. 4: In vivo antitumor therapeutic efficacy of AMT.
From: Amantadine against glioma via ROS-mediated apoptosis and autophagy arrest
A Representative tumor photos of the U251 tumor-bearing mice with different treatments (n = 5). B The tumor volumes of mice at indicated time points (n = 5). C The tumor weight of mice at indicated time points (n = 5). D Immunohistochemical staining of Ki-67. Scale bar: 50 μm. E Representative MRI image of tumors in the glioma orthotopic mouse model. F Kaplan–Meier curves of glioma orthotopic mice from (E) (n = 5). G, H Immunohistochemical staining of cleaved-caspase3 and LC3 in tumor tissues after different treatments. Scale bar: 50 μm. I Immunoblotting analysis of the cleaved-caspase3 and LC3 levels in these tumor tissues. Error bars indicate mean ± SD (**P < 0.01, ***P < 0.001).
