Fig. 6: Dual role of lipid peroxidation in cancer.
From: Emerging mechanisms of lipid peroxidation in regulated cell death and its physiological implications
On the one hand, chronic inflammation triggered by lipid peroxidation may lead to the polarization the macrophage in tumor microenvironment, which further induce the release of DAMPs and promote tumor growth. On the other hand, the excessive tumor cells death via lipid peroxidation not only remove the malignant cells but also cause the release of DAMPs, lead to the accumulation of immune cells to suppress tumor growth. Neutrophils, as the important innate immune cells, also have an important role in regulating tumor growth.
