Fig. 7: ED peptide stimulates optic nerve regeneration.
From: Marcks overexpression in retinal ganglion cells promotes optic nerve regeneration
A Top: experimental timeline. Bottom: representative image of optic nerve showing that intravitreal injection of ED peptide stimulated optic nerve regeneration 2 weeks after optic nerve crush. The right columns showed enlarged images of nerves at 500, and 1000 μm distal to the crush sites marked by white boxes on the left. Scale bar: 200 μm. *: crush sites. B Quantification of axon regeneration in (A). ****p < 0.0001, ***p < 0.001, **p < 0.01, ns no significance. n = 6–7 mice in each group. C Representative images of retinal sections from intact retina or injured retina 2 weeks after injury stained with RBPMS. Scale bar: 20 μm. D Quantification of RGC survival in (C) showing that intravitreal injection of ED peptide could not promote RGC survival rate. ns no significance. RGCs were analyzed from at least 7 non-adjacent retinal sections for each animal, from 4 mice per group.
