Fig. 2: PM2.5 promotes glycolysis metabolism in BEAS-2B and NSCLC cells. | Cell Death & Disease

Fig. 2: PM2.5 promotes glycolysis metabolism in BEAS-2B and NSCLC cells.

From: Downregulation of tRNA methyltransferase FTSJ1 by PM2.5 promotes glycolysis and malignancy of NSCLC via facilitating PGK1 expression and translation

Fig. 2

A PM2.5 increases the production of pyruvate from BEAS-2B cells, and the effect of PM2.5 on pyruvate production is suppressed by 2-DG. B PM2.5 enhances the generation of pyruvate from A549 cells in a dose response fashion, and 2-DG treatment alleviates the impacts of PM2.5 on pyruvate generation from A549 cells. C PM2.5 promotes pyruvate release from H358 cells, and 2-DG inhibits the effects of PM2.5 on pyruvate release from H358 cells. D PM2.5 augments L-lactate release from BEAS-2B cells, and 2-DG suppresses the effects of PM2.5 on L-lactate release from BEAS-2B cells. E PM2.5 up-regulates L-lactate levels in the culture medium A549 cells, while 2-DG downregulates the levels of PM2.5-induced L-lactate. F PM2.5 augments the production of L-lactate from H358 cells, and 2-DG represses PM2.5-induced L-lactate production from H358 cells. Data are presented as mean ± SD, Student’s t test. NS not significant; *p < 0.05, **p < 0.01, ***p < 0.001. All p values are versus control or similar PM2.5 exposure level group.

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