Fig. 7: Association of FTSJ1 and PGK1 expression with glucose uptake in patients with NSCLC. | Cell Death & Disease

Fig. 7: Association of FTSJ1 and PGK1 expression with glucose uptake in patients with NSCLC.

From: Downregulation of tRNA methyltransferase FTSJ1 by PM2.5 promotes glycolysis and malignancy of NSCLC via facilitating PGK1 expression and translation

Fig. 7

A Representative immunohistochemical staining (IHC) images of high and low FTSJ1 expression in tumor tissues from NSCLC patients. Scale bar: 5 µm. B Mean SUVmax score in FTSJ1 negative NSCLC tissue samples was higher than that of positive tissues. C FTSJ1 expression level in tumor tissues was negatively correlated with SUVmax score. D Representative IHC images of high and low PGK1 expression in tumor tissues of NSCLC patients. Scale bar: 5 µm. E Mean SUVmax score in PGK1 positive tissues was higher than that of PGK1 negative samples. F PGK1 expression level in NSCLC tumor tissues was positively correlated with SUVmax score. G FTSJ1 expression level was negatively correlated with PGK1 expression in NSCLC tumor tissues. H Representative image of 18FDG PET-CT scan in NSCLC patients with high FTSJ1 expression. The arrow reveals lower glucose uptake. I Representative image of 18FDG PET-CT scan in NSCLC patients with low FTSJ1 expression level in tumor tissues. The arrow points to higher glucose uptake. Data are presented as mean ± SD. Two-tailed paired t-test. *p < 0.05, **p < 0.01, ***p < 0.001.

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