Table 1 Drugs and factors affecting the level of MCL-1S isoform in different types of cancer cells by undetermined modes of action.
From: Tipping the balance of cell death: alternative splicing as a source of MCL-1S in cancer
Cell type | Cell line | Drugs/factors increasing MCL-1S level | Effect on the MCL-1L level | Ref. |
|---|---|---|---|---|
Acute myeloid leukemia | HL60 | YM155 | Downregulation | [73] |
Acute myeloid leukemia and chronic myeloid leukemia | HL60, K562 | α-tomatine | No substantial changes | [71] |
Acute T-cell leukemia | Jurkat | 5-fluorouracil | Downregulation | [72] |
Breast cancer | MCF-7 | Undecylprodigiosin | Unaltered | [67] |
Breast cancer | MCF-7 | N-methyl bis(indolyl)hydrazide-hydrazone derivative | Unaltered | [68] |
Breast cancer | MDA-MB-231 | Ethyl acetate fraction of Stylissa carteri | ND | [69] |
Cervical cancer | HeLa | M2I-1 + nocodazole | Slight upregulation | [62] |
Cholangiocarcinoma | QBC939 | Dihydroartemisinin | No substantial changes | [64] |
Cholangiocarcinoma | HUCCT-1, FRH0201 | Dihydroartemisinin + miR-29b | Downregulation | [41] |
Multiple myeloma | MM.1S | SDX-101 | No substantial changes | [70] |
Prostate cancer | PC-3 | Caseamembrin C | Slight upregulation | [65] |
Prostate cancer | DU145 | Isoangustone A | No substantial changes | [66] |
Prostate cancer | PC-3 | EGCG and ibuprofen | Downregulation | [32] |
Tongue squamous cell carcinoma | AW8507 | Irradiation | Upregulation | [74] |
Cell type | Cell line | Drugs decreasing MCL-1S level | Effect on the MCL-1L level | Ref. |
|---|---|---|---|---|
Head and neck squamous cell carcinoma | CAL27, UM-SCC1 | Curcumin (liposome-encapsulated) | Downregulation | [76] |
