Fig. 7: Comparison of expression levels of p63 WT and the ΔExon8 (ΔEx8) variant.
From: Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
A The mRNA levels corresponding to WT and ΔExon8mRNA were determined by quantitative RT-PCR in the indicated tissues. Both variants were only detectable in RNA preparations from skin, bladder, placenta and thymus. The detection limit was determined using a water sample for each primer pair. B The ratios of WT and ΔExon8 levels in the four tissues containing detectable p63 mRNA were significantly different between placenta on the one hand vs. bladder, skin and thymus on the other hand. Whereas both isoforms were almost equally expressed in placenta, WT was predominant in the other tissues.
