Fig. 7: Rock1 knockdown abolished the effects of Rnd3 on Dox-induced cardiac remodeling and dysfunction. | Cell Death & Disease

Fig. 7: Rock1 knockdown abolished the effects of Rnd3 on Dox-induced cardiac remodeling and dysfunction.

From: Rnd3 protects against doxorubicin-induced cardiotoxicity through inhibition of PANoptosis in a Rock1/Drp1/mitochondrial fission-dependent manner

Fig. 7

A Representative M-mode recordings of echocardiography of N-Tg or Rnd3-Tg mice injected with AAV9-shRNA-Control or AAV9-shRNA-Rock1, and then treated with Dox. B, C Quantitative analysis of LVEF and LVFS of heart (n = 3). D Quantitative analysis of HW/TL (n = 3). E Survival curves of the mice during the 4 W period (n = 12). F Representative ultrastructural images of Mitochondria obtained by transmission electron microscope following treatment with Dox, scale bar = 1 μm. G, H Quantitative analysis of mitochondrial number per field and mean mitochondrial size (n = 5). I, J Representative images and quantitative analysis of masson trichrome staining in the peripheral of heart following Dox treatment, scale bar = 20 μm. K, L Representative WGA staining images and quantification of indicated mice (n = 5). Data were presented as mean ± SD. One-way ANOVA was used for statistical analysis in (B)–(G), (H), (J), and (L).

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