Fig. 2: AURKBi induces persistent cell division failure. | Cell Death & Disease

Fig. 2: AURKBi induces persistent cell division failure.

From: Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells

Fig. 2

A Timeline of a single C33A cell followed for 3 days using time lapse microscopy. It shows that the majority of divisions resulted in two daughter cells. B The percentage of normal and failed cell divisions obtained from 3-day time lapse imaging of C33A and CaSki cells without and with 200 nM AZD2811 treatment. The data are from >50 cells for each condition. C Timelines for C33A and CaSki cells treated with AZD2811 as in (B) and followed for 3 days. D C33A and CaSki cells treated with either 1 μM alisertib or 300 nM AMG900 and followed for 3 days by time lapse microscopy. The percentage of failed cell divisions was determined for >50 cells per condition.

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