Fig. 3: AZD2811 treated cells have no long-term proliferative potential. | Cell Death & Disease

Fig. 3: AZD2811 treated cells have no long-term proliferative potential.

From: Aurora B inhibition induces hyper-polyploidy and loss of long-term proliferative potential in RB and p53 defective cells

Fig. 3

A Timeline of the experiment. Time lapse images of B control C33A cells, C, D C33A cells treated with 200 nM AZD2811. Cells were treated for 2 days then the drug was removed, and the cells were imaged from day 6 to 10. Images were collected every 30 min, and montage shows still images at 5 h intervals. Bars indicated 50 μm. E. Outcomes of cell division from the time lapse shown in (A–D) and a parallel experiment using CaSki cells. 100 cells were analysed for each condition. F Mitotic duration for C33A cells treated for 2 days with 200 nM AZD2811 then washed off and followed by time lapse microscopy from day 6 to 10. Statistical significance was assessed using a t-test; ***p < 0.001.

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