Fig. 1: KLF5 expression is increased in PDAC tissues. | Cell Death & Disease

Fig. 1: KLF5 expression is increased in PDAC tissues.

From: Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells

Fig. 1

A KLF5 mRNA expression levels in PDAC and para-cancerous tissue (n = 30, ****P < 0.0001). B KLF5 mRNA expression levels in PDAC from TCGA-PAAD and para-cancerous tissue matching TCGA normal and GTEx data (*P < 0.05). C Representative western blots in PDAC and para-cancerous tissue. D Data showing high expression of KLF5 in tumor tissues (n = 30, ****P < 0.001). E, F KLF5 expression across various clusters in PDAC from two single-cell RNA-sequencing datasets (GEO: GSE155698, GSE202051). G Western blots of KLF5 expression in HPDE and PDAC cell lines. H Representative images of KLF5 in IHC staining in PDAC and para-cancerous tissues (scale bar, 200 μm). I KLF5 expression in PDAC and para-cancerous tissues, as evaluated by IHC score (n = 48, ****P < 0.0001). J Representative images of IHC staining for KLF5 in TMAs (scale bar, 200 µm, 50 µm). K OS of PDAC patients was analyzed using Kaplan–Meier analysis according to KLF5 expression in our center (ZSHFU) (n = 82, *P = 0.0112). L OS of PDAC patients was evaluated using Kaplan–Meier analysis according to KLF5 expression (n = 125, *P = 0.04) from the PDAC dataset (GEO: GSE71729).

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