Fig. 5: KLF5 relies on ZEB1 to regulate ferroptosis. | Cell Death & Disease

Fig. 5: KLF5 relies on ZEB1 to regulate ferroptosis.

From: Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells

Fig. 5

A HMOX1 protein was detected in CFPAC-1 and Capan-1 cells treated by shKLF5 or shHMOX1 or both. B ZEB1-downregulated CFPAC-1 and Capan-1 cells were treated with 2.5 μmol/L Erastin and/ or 2 μmol/L Fer-1 for 16 h and cell death was analyzed by PI labeling. C, D CFPAC-1 and Capan-1 cells were subjected to the same treatment, and lipid peroxidation was detected using BODIPY 581/591 C11. E CFPAC-1 and Capan-1 cells were subjected to the same treatment and lipid peroxidation was analyzed using confocal microscopy. F CFPAC-1 and Capan-1 cells were subjected to the same treatment and the lipid peroxidation was analyzed using MDA.

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