Fig. 1: MPTP administration caused dopaminergic neuron loss in the SNpc and motor dysfunction. | Cell Death & Disease

Fig. 1: MPTP administration caused dopaminergic neuron loss in the SNpc and motor dysfunction.

From: Infiltrating peripheral monocyte TREM-1 mediates dopaminergic neuron injury in substantia nigra of Parkinson’s disease model mice

Fig. 1

a Time course of MPTP administration and behavior tests in mice. b, c Global view of the substantia nigra in a C57BL/6 J mouse. d, e Representative images of immunofluorescence staining of TH and quantification of TH+ dopaminergic neurons in the SNpc. Scale bars: 200 μm for the top row and 100 μm for the bottom row. (n = 9 sections/3 mice per group). f Western blot analysis of TH in the SNpc of naive mice and mice treated with saline or MPTP (n = 4). g MPTP injection significantly decreased striatal dopamine content as measured by HPLC (n = 4). h Movement paths in OFT in different experimental groups. i Total distance moved in the OFT (n = 8–11). j Latency to fall off the rod on the rotarod (n = 6). k Latency to descend in the pole (n = 8). The data are presented as the mean ± SEM. (*P < 0.05, **P < 0.01, or ***P < 0.001 by one-way ANOVA).

Back to article page